Published January 1, 2015
| Version v1
Journal article
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Inhibition of Aspergillus fumigatus and Its Biofilm by Pseudomonas aeruginosa Is Dependent on the Source, Phenotype and Growth Conditions of the Bacterium
Creators
- 1. Calif Inst Med Res, San Jose, CA 95128 USA
- 2. Stanford Univ, Dept Pediat, Div Pulmonol, Stanford, CA 94305 USA
- 3. Stanford Univ, Dept Civil & Environm Engn, Stanford, CA 94305 USA
- 4. Stanford Univ, Dept Pathol, Stanford, CA 94305 USA
- 5. Lisbon Sch Hlth Technol, Escola Super Tecnol Saude Lisboa, Lisbon, Portugal
Description
Aspergillus fumigatus (Af) and Pseudomonas aeruginosa (Pa) are leading fungal and bacterial pathogens, respectively, in many clinical situations. Relevant to this, their interface and co-existence has been studied. In some experiments in vitro, Pa products have been defined that are inhibitory to Af. In some clinical situations, both can be biofilm producers, and biofilm could alter their physiology and affect their interaction. That may be most relevant to airways in cystic fibrosis (CF), where both are often prominent residents.
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