Published January 1, 2015
| Version v1
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Locomotor stimulation by acute propofol administration in rats: Role of the nitrergic system
- 1. Ankara Numune Training & Res Hosp, Dept Anaesthesiol & Reanimat, Ankara, Turkey
- 2. Uskudar Univ, Neuropsychopharmacol Applicat & Res Ctr NPARC, Istanbul, Turkey
- 3. Duzce Univ, Fac Med, Dept Anaesthesiol & Reanimat, Duzce, Turkey
Description
Background: The addictive potential of propofol has been scientifically discussed. Drugs' psychostimulant properties that can be assessed via measurements of locomotor activity are linked to their addictive properties. No studies that have investigated the effects of propofol on locomotor activity have been reported to date. The present study sought to investigate the effects and possible mechanisms of action of propofol on locomotor activity in rats.
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