Published January 1, 2020
| Version v1
Journal article
Open
Silencing HMGB1 expression inhibits adriamycin's heart toxicity via TLR4 dependent manner through MAPK signal transduction
Creators
- 1. Nigde Omer Halisdemir Univ, Fac Med, Dept Physiol, Nigde, Turkey
- 2. Nigde Omer Halisdemir Univ, Fac Med, Dept Biophys, Nigde, Turkey
- 3. Duzce Univ, Fac Arts & Sci, Dept Biol, Duzce, Turkey
- 4. Istanbul Univ, Aziz Sancar Expt Med Res Inst, Dept Genet, Istanbul, Turkey
- 5. Adiyaman Univ, Fac Arts & Sci, Dept Biol, Adiyaman, Turkey
- 6. Istanbul Univ, Fac Med, Dept Biophys, Istanbul, Turkey
Description
Purpose: Adriamycin (APR) is a commonly used anti-cancer drug. ADR has toxic effects on cardiomyocytes and leads to heart failure. However, the underlying mechanism(s) by which ADR causes heart failure is still not clarified exactly. The aim of present study is to investigate whether ADR-induced heart failure is mediated via HMGB1/TLR4 to initiate the apoptosis through MAPK/AMPK pathways.
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