Published January 1, 2020 | Version v1
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Evaluation of Caco-2 cell permeability of ritonavir nanosuspensions

  • 1. Gazi Univ, Dept Pharmaceut Technol, Fac Pharm, Ankara, Turkey
  • 2. Inonu Univ, Dept Pharmaceut Technol, Fac Pharm, Malatya, Turkey

Description

Background and Aims: Poor aqueous solubility limits drug absorption through intestinal mucosa. Nanosuspensions with nanometer range particle size provides enhanced aqueous solubility and hence permeability. The objective of this study was to investigate the cytotoxicity and in vitro cell permeability through human adenocarcinoma (Caco-2) cells of ritonavir (RTV) nanosuspensions.

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