Published January 1, 2015
| Version v1
Journal article
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The Antinociceptive and Antiinflammatory Properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a Positive Allosteric Modulator of alpha 7 Nicotinic Acetylcholine Receptors in Mice
Creators
- 1. Med Univ Lublin, Dept Biopharm, Lab Med Chem & Neuroengn, Lublin, Poland
- 2. Pontificia Univ Catolica Chile, Fac Chem, Dept Organ Chem, Santiago, Chile
- 3. Calif Northstate Univ, Coll Med, Dept Med Educ, Elk Grove, CA USA
- 4. Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA
Description
BACKGROUND: Positive allosteric modulators (PAMs) facilitate endogenous neurotransmission and/or enhance the efficacy of agonists without directly acting on the orthosteric binding sites. In this regard, selective 7 nicotinic acetylcholine receptor type II PAMs display antinociceptive activity in rodent chronic inflammatory and neuropathic pain models. This study investigates whether 3-furan-2-yl-N-p-tolyl-acrylamide (PAM-2), a new putative 7-selective type II PAM, attenuates experimental inflammatory and neuropathic pains in mice.
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