Published January 1, 2015
| Version v1
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The relationship between estrogen receptors and microtubule dynamics in post-menopausal rat brain
Creators
- 1. Kafkas Univ, Fac Med, Dept Histol & Embryol, TR-36100 Kars, Turkey
- 2. Kafkas Univ, Fac Med, Dept Microbiol, TR-36100 Kars, Turkey
- 3. Ataturk Univ, Fac Vet, Dept Pharmacol & Toxicol, TR-25240 Erzurum, Turkey
- 4. Ataturk Univ, Fac Med, Dept Anat, TR-25240 Erzurum, Turkey
- 5. Ataturk Univ, Fac Med, Dept Histol & Embryol, TR-25240 Erzurum, Turkey
- 6. Ataturk Univ, Fac Med, Dept Pathol, TR-25240 Erzurum, Turkey
Description
Introduction: Estrogen is one of the most important regulators of neuron function. There is a broad consensus that a loss of estrogen is associated with neurodegeneration in the hippocampus which leads to cognitive impairment. Hematopoietic-Pbx-interaction-protein (HPIP) is a novel scaffolding protein which interacts with microtubules and estrogen receptors. In this study, we investigated the presence and role of HPIP in hippocampal neurons and examined the relationship between estrogen receptors and microtubule damage in post-menopausal rat brains.
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