Published January 1, 2015
| Version v1
Journal article
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PAT1 inversely regulates the surface Amyloid Precursor Protein level in mouse primary neurons
Creators
- 1. Univ Paris 05, Sorbonne Paris Cite, INSERM, Fac Med,UMR 894, Paris, France
- 2. Univ Naples 2, Sch Med, Dept Biochem Biophys & Gen Pathol, Naples, Italy
Description
Background: The amyloid precursor protein (APP) is a key molecule in Alzheimer disease. Its localization at the cell surface can trigger downstream signaling and APP cleavages. APP trafficking to the cell surface in neurons is not clearly understood and may be related to the interactions with its partners. In this respect, by having homologies with kinesin light chain domains and because of its capacity to bind APP, PAT1 represents a good candidate.
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