Published January 1, 2015
| Version v1
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A Possible Role for WNT5A Hypermethylation in Pediatric Acute Lymphoblastic Leukemia
Creators
- 1. Istanbul Univ, Fac Med, Inst Expt Med Res DETAE, Dept Genet, Istanbul, Turkey
- 2. Istanbul Univ, Fac Med, Dept Pediat Hematol & Oncol, Istanbul, Turkey
- 3. Akdeniz Univ, Fac Med, Dept Pediat Hematol & Oncol, TR-07058 Antalya, Turkey
- 4. Istanbul Univ, Cerrahpasa Fac Med, Dept Pediat Hematol & Oncol, Istanbul, Turkey
- 5. Kanuni Sultan Suleyman Res & Training Hosp, Clin Pediat Hematol & Oncol, Istanbul, Turkey
- 6. Sisli Etfal Res & Training Hosp, Clin Pediat Hematol & Oncol, Istanbul, Turkey
- 7. Medeniyet Univ, Goztepe Res & Training Hosp, Clin Pediat Hematol & Oncol, Fac Med, Istanbul, Turkey
Description
Objective: WNT5A is one of the most studied noncanonical WNT ligands and is shown to be deregulated in different tumor types. Our aim was to clarify whether hypermethylation might be the cause of low WNT5A mRNA levels and whether we could restore this downregulation by reversing the event.
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