Yayınlanmış 1 Ocak 2015
| Sürüm v1
Dergi makalesi
Açık
Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens
Oluşturanlar
- 1. Hacettepe Univ, Dept Chem, TR-06800 Ankara, Turkey
- 2. Istanbul Kemerburgaz Univ, Sch Med, TR-34217 Istanbul, Turkey
- 3. Biodonostia Res Inst, Donostia San Sebastian 20014, Spain
- 4. Gazi Univ, Fac Sci, Dept Chem, TR-06500 Ankara, Turkey
- 5. Gazi Univ, Biochem Proc & Biomat Res Lab, TR-06500 Ankara, Turkey
Açıklama
In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.
Dosyalar
bib-e46d8b7e-75a2-4982-8c73-90f3fc4178a3.txt
Dosyalar
(258 Bytes)
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