Published January 1, 2015
| Version v1
Journal article
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Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens
Creators
- 1. Hacettepe Univ, Dept Chem, TR-06800 Ankara, Turkey
- 2. Istanbul Kemerburgaz Univ, Sch Med, TR-34217 Istanbul, Turkey
- 3. Biodonostia Res Inst, Donostia San Sebastian 20014, Spain
- 4. Gazi Univ, Fac Sci, Dept Chem, TR-06500 Ankara, Turkey
- 5. Gazi Univ, Biochem Proc & Biomat Res Lab, TR-06500 Ankara, Turkey
Description
In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.
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