Anticancer, photoluminescence and electrochemical properties of structurally characterized two imine derivatives

Two imine compounds, 4-[(E)-(2-methoxybenzylidene)amino]phenol (L-1) and 4-[(E)-(3,4-dimethoxybe nzylidene)amino]phenol (L-2) were synthesized and characterized by the analytical and spectroscopic methods. The electrochemical and photoluminescence properties of the imine compounds L-1 and L-2 were investigated in different solvents. The compounds L-1 and L-2 show different redox processes at some potentials. The molecular structures of two Schiff base compounds are broadly similar, differing principally in the position, the number of methoxy (-OCH3) groups and dihedral angles between aromatic rings. While the compound L-1 has only one methoxy group located on the o-position with respect to the imine bond (C=N), the L-2 contains two methoxy groups on the p-m-positions with respect to the imine bond. The imine compounds show two or three emission bands in the 619-832 nm range in organic solvents. In the 1.0 x 10(-3) M concentration, the compounds have the highest excitation and emission bands. The imine compounds L-1 and L-2 were screened for their in vitro cytotoxicity on HeLa cell lines using the xCELLigence system (Real Time Cell Analyzer). (C) 2015 Elsevier B.V. All rights reserved.