Published January 1, 2015
| Version v1
Journal article
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Hypoxic metabolism in human hematopoietic stem cells
Creators
- 1. Bingzhou Med Univ, Taishan Scholar Program, Yantai 264003, Peoples R China
- 2. Shanghai Jiao Tong Univ, Sch Med, Key Lab Cell Differentiat & Apoptosis, Chinese Minist Educ, Chongqing 200025, Shanghai, Peoples R China
- 3. Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA
- 4. El Galaa Hosp, Dept Clin Pathol, Cairo, Egypt
- 5. Ain Shams Univ, Fac Med, Cairo, Egypt
- 6. Shanghai Jiao Tong Univ, Shanghai Tongren Hosp, Fac Basic Med, Sch Med,Hongqiao Int Inst Med, Shanghai 200025, Peoples R China
Description
Background: Adult hematopoietic stem cells (HSCs) are maintained in a microenvironment, known as niche in the endosteal regions of the bone marrow. This stem cell niche with low oxygen tension requires HSCs to adopt a unique metabolic profile. We have recently demonstrated that mouse long-term hematopoietic stem cells (LT-HSCs) utilize glycolysis instead of mitochondrial oxidative phosphorylation as their main energy source. However, the metabolic phenotype of human hematopoietic progenitor and stem cells (HPSCs) remains unknown.
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