Yayınlanmış 1 Ocak 2015 | Sürüm v1
Dergi makalesi Açık

Genome-wide target analysis of NEUROD2 provides new insights into regulation of cortical projection neuron migration and differentiation

  • 1. Koc Univ, Mol Biol & Genet Dept, TR-34450 Istanbul, Turkey
  • 2. Koc Univ, Dept Phys, TR-34450 Istanbul, Turkey

Açıklama

Background: Cellular differentiation programs are controlled, to a large extent, by the combinatorial functioning of specific transcription factors. Cortical projection neurons constitute the major excitatory neuron population within the cortex and mediate long distance communication between the cortex and other brain regions. Our understanding of effector transcription factors and their downstream transcriptional programs that direct the differentiation process of cortical projection neurons is far from complete.

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