Published January 1, 2019
| Version v1
Journal article
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Synthesis, Molecular Modelling and Antibacterial Activity Against Helicobacter pylori of Novel Diflunisal Derivatives as Urease Enzyme Inhibitors
Creators
- 1. Cumhuriyet Univ, Dept Pharmaceut Chem, Fac Pharm, Sivas, Turkey
- 2. Kadir Has Univ, Fac Engn & Nat Sci, Dept Bioinformat & Genet, Istanbul, Turkey
- 3. Yeditepe Univ, Dept Genet & Bioengn, Fac Engn & Architecture, Istanbul, Turkey
- 4. Marmara Univ, Dept Pharmaceut Chem, Fac Pharm, Istanbul, Turkey
Description
Background: The main factor for the prolongation of the ulcer treatment in the gastrointestinal system would be Helicobacter pylori infection, which can possibly lead to gastrointestinal cancer. Triple therapy is the treatment of choice by today's standards. However, observed resistance among the bacterial strains can make the situation even worse. Therefore, there is a need to discover new targeted antibacterial therapy in order to make success in the eradication of H. pylori infections.
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