Published January 1, 2019
| Version v1
Journal article
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Differential effects of adenylyl cyclase-protein kinase A cascade on shear-induced changes of sickle cell deformability
Creators
- 1. Koc Univ, Dept Physiol, Sch Med, Istanbul, Turkey
- 2. Hop Edouard Herriot, Clin Med Ambulatoire Hematol, Lyon, France
- 3. Hosp Civils Lyon, IHOP, Lyon, France
Description
BACKGROUND: Erythrocyte deformability is impaired in sickle cell disease (SCD). The regulation of cytoskeletal protein organization plays a key role in erythrocyte deformability. The activation of adenylyl cyclase (AC)/cAMP/Protein kinase A (PKA) signaling pathway was associated with increased deformability in healthy erythrocytes, however the role of this pathway in SCD is unknown.
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