Published January 1, 2019
| Version v1
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A three-component, one-pot synthesis of 1,8-naphthyridine and isoxazole derivatives and computational elucidation of the mechanism
- 1. Yildiz Tech Univ, Dept Chem, Fac Arts & Sci, Davutpasa Campus, TR-34220 Esenler, Turkey
- 2. Marmara Univ, Dept Chem, Fac Arts & Sci, TR-34722 Istanbul, Turkey
- 3. San Francisco State Univ, Dept Chem & Biochem, 1600 Holloway Ave, San Francisco, CA 94132 USA
- 4. Kirsehir Ahi Evran Univ, Dept Chem, TR-40100 Kirsehir, Turkey
Description
An efficient and general method for the synthesis of substituted 3,4-dimethylisoxazolo[5,4-b]pyridine-5-carboxamide and benzo[b][1,8]naphthyridine-3-carboxamide derivatives by using 2,2,6-trimethyl-4H-1,3-dioxin-4-one, benzyl amine, aromatic aldehydes, 2-aminoquinoline, or 5-amino-3-methylisoxazole in the presence of a catalytic amount of p-toluenesulfonic acid or iodine is described. The formation of the products was investigated and the results obtained were also supported by theoretical calculations.
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