Published January 1, 2019
| Version v1
Journal article
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NF-kappa B-Induced Upregulation of miR-548as-3p Increases Invasion of NSCLC by Targeting PTEN
Creators
- 1. Pamukkale Univ, Dept Med Biol, Denizli, Turkey
- 2. Akdeniz Univ, Dept Med Biol & Genet, Antalya, Turkey
- 3. Antalya Training & Res Hosp, Pathol Dept, Antalya, Turkey
- 4. Antalya Training & Res Hosp, Med Oncol, Antalya, Turkey
Description
Background: Non-Small Cell Lung Cancer (NSCLC) is an aggressive cancer type due to high metastatic capacity. Nuclear Factor Kappa B (NF-kappa B) is a consistently active transcription factor in malignant lung cancer cells and has crucial significance in NSCLC progression. It is also implicated in the transcriptional regulation of many genes including microRNAs (miRNAs) that function as tumor suppressor or oncogene. It has been increasingly reported that several miRNAs defined as gene members are induced by NF-kappa B. The present study aimed to find novel miRNAs that are regulated by NF-kappa B.
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