Published January 1, 2019
| Version v1
Journal article
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The effects Metformin/Irinotecan-loaded PLGA nanoparticles on glutamate re-uptake time and alteration EAAT1 gene expression level in vitro
Creators
- 1. Ataturk Univ, Dept Pharmacol & Toxicol, Fac Vet, TR-25240 Erzurum, Turkey
- 2. Ataturk Univ, Dept Med Pharmacol, Fac Med, TR-25240 Erzurum, Turkey
- 3. Ataturk Univ, Dept Pharmaceut Technol, Fac Pharm, TR-25240 Erzurum, Turkey
- 4. Usak Univ, Dept Med Pharmacol, Fac Pharm, TR-64000 Usak, Turkey
Description
Objective(s): The present study was designed to evaluate of Metformin/Irinotecan-loaded poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) effects on glutamate re-uptake time and receptor expression status in both glioblastoma multiforme (GBM) and cortex neuron cultures. The study was performed on glioblastoma cell line and primer cortex neuron.
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