Yayınlanmış 1 Ocak 2019
| Sürüm v1
Dergi makalesi
Açık
Synthesis of novel Azol-beta-lactam derivatives starting from phenyl piperazine and investigation of their antiurease activity and antioxidant capacity comparing with their molecular docking studies
- 1. Karadeniz Tech Univ, Dept Chem, TR-61080 Trabzon, Turkey
- 2. Karadeniz Tech Univ, Dept Chem & Chem Proc Technol, TR-61080 Trabzon, Turkey
- 3. Recep Tayyip Erdogan Univ, Dept Chem, TR-53100 Rize, Turkey
Açıklama
This study reports the synthesis, biological investigation and molecular docking of novel beta-lactam derivatives bearing 1,3,4-thiadiazole and 1,3,4-oxadiazole ring system. The synthesized compounds were evaluated for in vitro antiurease activity and antioxidant capacity. Almost all compounds showed excellent antiurease activity compared to thiourea, standard drug. Also, in silico ADME (absorption, distribution, metabolism, elimination) prediction and molecular docking studies were performed. (C) 2019 Elsevier B.V. All rights reserved.
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