Yayınlanmış 1 Ocak 2019
| Sürüm v1
Dergi makalesi
Açık
Platinum (II) N-heterocyclic carbene complexes: Synthesis, characterization and cytotoxic properties
Oluşturanlar
- 1. Inonu Univ, Catalysis Res & Applicat Ctr, TR-44280 Malatya, Turkey
- 2. Pamukkale Univ, Dept Pharmacol, Fac Med, TR-20070 Denizli, Turkey
- 3. Inonu Univ, Fac Sci & Arts, Dept Chem, TR-4280 Malatya, Turkey
- 4. Akdeniz Univ, Serik Gulsun Suleyman Sural Vocat Sch Higher Educ, Dept Opticianry Program, TR-07070 Antalya, Turkey
- 5. Dokuz Eylul Univ, Dept Phys, Fac Sci, TR-35160 Izmir, Turkey
Açıklama
Platinum (II) complexes bearing N-heterocyclic carbene (NHC) ligands have been widely used in catalytic chemistry, but there are very few reports of biological properties of this type of complexes. A series of [PtCl2(NHC)(PEt3)] complexes were synthesized. The structures of all compounds were characterized by H-1-NMR, C-13-NMR, IR and elemental analysis techniques, which supported the proposed structures. The single crystal structures of complexes 1a and 1e were determined. The title complexes show slightly distorted square-planar coordination around the platinum (II) metal center. The cytotoxic properties of the platinum (II)-NHC complexes have been assessed in various human cancer lines, including cisplatin-sensitive and resistant cells. IC50 values of these four complexes were determined by the MTS-based assay on three human cell lines-brain (SHSY5Y), colon (HTC116) and liver (HEP3B). These complexes have been highlighted cancer therapeutic agent with unique structures and functions.
Dosyalar
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