Published January 1, 2019
| Version v1
Journal article
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Inflammation increases MMP levels via PGE(2) in human vascular wall and plasma of obese women
Creators
- 1. Istanbul Univ, Fac Pharm, Dept Pharmacol, TR-34116 Istanbul, Turkey
- 2. Univ Sousse, Fac Med Sousse, Dept Physiol & Funct Explorat, UR 12ES06, Sousse, Tunisia
- 3. CHU Xavier Bichat, Eicosanoids & Vasc Pharmacol Grp, INSERM U1148, LVTS, 46 Rue Huchard, F-75018 Paris, France
Description
Background and objectives: Matrix metalloproteinases (MMPs) are involved in several inflammatory processes including obesity-related vascular diseases and graft failure of coronary artery (CA) bypass grafts [internal mammary artery (IMA), saphenous vein (SV)]. In these inflammatory conditions, the release of prostaglandin E-2 (PGE(2)) is increased via the activity of inducible microsomal PGE synthase-1 (mPGES-1). Our aim was to investigate whether MMPs and their endogenous inhibitor (TIMPs) may be regulated by PGE(2) under inflammatory conditions in human vasculature and perivascular adipose tissue (PVAT), as well as in plasma of obese patients.
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