Published January 1, 2019
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Secondary metabolites from Scutellaria albida L. ssp. velenovskyi (Rech. f.) Greuter & Burdet
- 1. Univ Athens, Dept Pharm, Fac Life Sci, Sect Pharmacognosy & Chem Nat Prod, Athens 15771, Greece
- 2. Yeditepe Univ, Fac Pharm, Dept Pharmacognosy, TR-34755 Istanbul, Turkey
Description
Fourteen compounds (Fig.1) were isolated from the aerial parts of Scutellaria albida L. ssp. velenovskyi (Rech. f.) Greuter & Burdet, including four iridoids (1-4) catalpol, macfadienoside, mussaenosidic acid, albidoside; four flavonoids (5-8) hispidulin 7-O-beta-D-glucuronide, scutellarin, xanthomicrol, eriodictyol; four phenylethanoid glycosides (9-12) verbascoside, leucosceptoside A, martynoside, 2-(3-hydroxy-4-methoxy-phenyl)-ethyl-1-O-beta-D-glucopyranoside; the sugar ester 6'-beta-D-glucopyranosyl-E-p-coumarate (13), as well as the acetogenic glucoside (Z)-3-hexenyl-1-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranoside (14). The structures of the isolates were established by means of NMR and HRMS spectral analyses. This is the first phytochemical study on S. velenovskyi and the first report of an acetogenic glycoside in the genus Scutellaria L. A chemical review on the isolated secondary metabolites in this study has been carried out. The chemotaxonomic value of the isolates is also discussed. Based on the literature data, the analysis revealed that the chemical profile of S. velenovskyi is close to that of the taxa belonging to the S. albida group.
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