Antimicrobial and anti-quorum-sensing properties and paint film usage of novel diazaborine-based copolymers

To meet high hygiene requirements, intensive studies are being carried out on antimicrobial materials. This study reports the synthesis of 3-((1-hydroxybenzo[d][1,2,3]diazaborinin-2(1H)-yl)sulfonyl)propyl methacrylate (DAZBMA) and its polymer, which is antimicrobial [tested with Staphylococcus aureus (ATCC 25923 and MU 40) and Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, and Candida albicans ATCC 10239] on solid surfaces. Antibiofilm capability was tested against MU 40. Although DAZBMA and its polymer show a high quorum-sensing inhibition property (tested with Chromobacterium violaceum CV 026 and CV 12472 and P. aeruginosa PA01), the lesser antibacterial activity of the polymer was improved by copolymerizing DAZBMA with quaternized 2-dimethylaminoethyl methacrylate. The paint films containing the prepared copolymer are highly active against all tested bacteria and show an antibiofilm effect against hospital-acquired multiple-antibiotic-resistant MU 40. The novel copolymer can be used in water-soluble paints to reduce its biofilm production and pathogenicity, especially for paints used in hospitals. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 46907.