Published January 1, 2019 | Version v1
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FoxO transcription factors 1 regulate mouse preimplantation embryo development

  • 1. Akdeniz Univ, Sch Med, Dept Histol & Embryol, TR-07070 Antalya, Turkey
  • 2. Biruni Univ, Sch Med, Dept Histol & Embryol, Istanbul, Turkey
  • 3. Univ Cambridge, Dept Physiol Dev & Neurosci, Mammalian Embryo & Stem Cell Grp, Cambridge CB2 3EG, England

Description

Purpose The aim of the present study is to investigate role of FoxO transcription factors in preimplantation embryo development by knocking down FoxO1, FoxO3, and FoxO4 genes and also to assess cell cycle arrest related proteins, p53 and p21, and apoptosis-related proteins, fas ligand (FASL), and cleaved caspase 3.

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