Published January 1, 2020
| Version v1
Journal article
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Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer
Creators
- 1. Balikesir Univ, Fac Sci & Arts, Dept Mol Biol & Genet, TR-10145 Balikesir, Turkey
- 2. Canakkale Onsekiz Mart Univ, Fac Sci & Arts, Dept Chem, Nat Prod & Drug Res Lab, TR-17020 Canakkale, Turkey
- 3. Gebze Tech Univ, Dept Chem, Fac Sci, TR-41400 Gebze, Turkey
- 4. Gaziantep Univ, Fac Sci & Arts, Dept Chem, TR-27310 Gaziantep, Turkey
Description
Prodrugs for targeted tumor therapies have been extensively studied in recent years due to not only maximising therapeutic effects on tumor cells but also reducing or eliminating serious side effects on healthy cells. This strategy uses prodrugs which are safe for normal cells and form toxic metabolites (drugs) after selective reduction by enzymes in tumor tissues.
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