Published January 1, 2019
| Version v1
Journal article
Open
Novel MIPs-Parabens based SPE Stationary Phases Characterization and Application
Creators
- 1. Univ Chieti Pescara G dAnnunzio, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy
- 2. Florida Int Univ, Int Forens Res Inst, Dept Chem & Biochem, 11200 SW 8th St, Miami, FL 33199 USA
- 3. Cumhuriyet Univ, Fac Sci, Dept Chem, TR-58140 Sivas, Turkey
- 4. Cumhuriyet Univ, Fac Pharm, Dept Analyt Chem, TR-58140 Sivas, Turkey
- 5. Univ Chieti Pescara G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Via Vestini 31, I-66100 Chieti, Italy
- 6. Hosp Santo Spirito, Pharmatoxicol Lab, Via Fonte Romana 8, I-65124 Pescara, Italy
- 7. Univ Chieti Pescara G dAnnunzio, Sect Legal Med, Dept Med & Aging Sci, Via Vestini 31, I-66100 Chieti, Italy
- 8. IRCCS Neurol Inst Fdn Carlo Besta, Lab Neurol Biochem & Neuropharmacol, Via Celoria 11, I-20133 Milan, Italy
- 9. Univ Camerino, Sch Sci & Technol, Chem Sci Dept, Piazza Cavour 19-f, I-62032 Camerino, Italy
- 10. Univ Bologna, Dept Chem G Ciamician, Via Selmi 2, I-40126 Bologna, Italy
Description
In this work, the synthesis, characterization, and application of novel parabens imprinted polymers as highly selective solid-phase extraction (SPE) sorbents have been reported. The imprinted polymers were created using sol-gel molecular imprinting process. All the seven parabens were considered herein in order to check the phase selectivity. By means of a validated HPLC-photodiode array detector (PDA) method all seven parabens were resolved in a single chromatographic run of 25 min. These SPE sorbents, in-house packed in SPE empty cartridges, were first characterized in terms of extraction capability, breakthrough volume, retention volume, hold-up volume, number of theoretical plates, and retention factor. Finally, the device was applied to a real urine sample to check the method feasibility on a very complex matrix. The new paraben imprinted SPE sorbents, not yet present in the literature, potentially encourage the development of novel molecularly imprinted polymers (MIPs) to enhance the extraction efficiency, and consequently the overall analytical performances, when the trace quantification is required.
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