Phytochemical constituents from Galanthus alpinus Sosn. var. alpinus and their anticholinesterase activities

Phytochemical studies on Galanthus alpinus Sosn. var. alpinus from Turkey resulted in the isolation of 11 metabolites including, 1 terpenoid; (+)-blumenol A 1, 2 lignans; pinoresinol 2 and epipinoresinol 3, and 8 other compounds; (+)-homolycorine 4, (+)-8-O-demethylhomolycorine 5, arolycoricidine 6, N-Trans-feruloyltyramine 7, (-)-lycorine 8, nicotinic acid 9, O-methylnorbelladine 10 and hordenine 11. To the best of our knowledge, all compounds are reported for the first time from the title species. The chemical structures of the compounds were elucidated by MS, 1D and 2D experiments. Also, isolated compounds were subjected to in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity assays. (C) 2018 SAAB. Published by Elsevier B.V. All rights reserved.