Published January 1, 2019
| Version v1
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Cucurbit[7]uril-Anchored Porphyrin-Based Multifunctional Molecular Platform for Photodynamic Antimicrobial and Cancer Therapy
- 1. Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey
Description
Here we report a photoactive supramolecular assembly that is multifunctional and constructed by covalently linking four receptor molecules (cucurbit[7]uril) to a porphyrin derivative with suitable linkers. While this molecular platform serves very efficiently as a light-triggered broad-spectrum antibacterial agent, owing to its negligible dark cytotoxicity and the presence of host molecules (CB7), it can also be utilized as a vehicle to carry drug molecules for a combined chemo and photodynamic cancer therapy.
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