Published January 1, 2019
| Version v1
Journal article
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Design, Synthesis and Investigation of New Diphenyl Substituted Pyridazinone Derivatives as Both Cholinesterase and A beta-Aggregation Inhibitors
Creators
- 1. Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, Ankara, Turkey
- 2. Eastern Mediterranean Univ, Fac Pharm, Dept Pharmaceut Chem, Gazimagosa, North Cyprus, Turkey
- 3. Hacettepe Univ, Dept Chem, Ankara, Turkey
- 4. Gazi Univ, Fac Med, Dept Immunol, Ankara, Turkey
Description
Background: With respect to the increase in the average life expectancy, Alzheimer Disease (AD), the most common form of age-related dementia, has become a major threat to the population over the age of 65 during the past several decades. The majority of AD treatments are focused on cholinergic and amyloid hypotheses.
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