Published January 1, 2019
| Version v1
Journal article
Open
Optimization of Different Surface Modifications for Binding of Tumor Cells in a Microfluidic Systems
Creators
- 1. Inst Hlth Sci, Translat Oncol Dept, Izmir, Turkey
- 2. Inst Sci & Technol, Chem Engn, Kocaeli, Turkey
- 3. Fac Mech Engn, Mechatron Dept, Istanbul, Turkey
- 4. Dokuz Eylul Univ, Inst Oncol, Dept Translat Oncol, Izmir, Turkey
- 5. Inst Oncol, Dept Translat Oncol, Izmir, Turkey
Description
Objectives:Microfluidic technology is a fast-growing area and provide high-efficient MEMS (Micro-Electro-Mechanical-Systems) sensor integration platform that helps to advance healthcare systems. Due to proper the chemical and mechanical properties of polymers, PDMS (Polydimethylsiloxane) (6) and PMMA (Poly-methyl-methacrylate), they became on the best candidate for health care studies in microfluidic studies (7). Besides, they perform great optical properties for observation of living cell experiments. To increase their performance, surface interactions works with cells, modification techniques are widely used in microfluidic chips. In this paper, our primary purpose is to modify such polymers and glass with matrigel, PDA and APTES so as to increase cell-surface interaction.
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