The Effects of in vitro Hyperglycemic Incubation on A23187-Mediated Contractile Responses of Rat Thoracic Aorta

Objective: Vascular tonus has been controlled by several factors secreted from endothelium in physiological conditions. In the present study, the possible changes on endothelium-derived contractile responses in normoglycemic and hyperglycemic conditions in terms of exposure-time dependency has been investigated.