Published January 1, 2019
| Version v1
Journal article
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Anti-metastatic effect of ranolazine in an in vivo rat model of prostate cancer, and expression of voltage-gated sodium channel protein in human prostate
Creators
- 1. Istanbul Univ, Fac Sci, Dept Biol, TR-34134 Istanbul, Turkey
- 2. Imperial Coll London, Dept Life Sci, Sir Alexander Fleming Bldg, London SW7 2AZ, England
- 3. Marmara Univ, Dept Pathol, Sch Med, Istanbul, Turkey
- 4. Inst Canc Res, Fulham Rd, London SW3 6JB, England
- 5. HCA Healthcare UK, Cellular Pathol Labs, GPS House,215 Great Portland St, London W1W 5PN, England
Description
Background Voltage-gated Na+ channels (VGSCs) are functionally upregulated in rat and human prostate cancer (PCa) where channel activity promotes cellular invasiveness in vitro and metastasis in vivo. Ranolazine is a clinically used VGSC inhibitor/anti-anginal drug, which has been shown previously to inhibit breast cancer metastasis in vivo.
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