Yayınlanmış 1 Ocak 2019
| Sürüm v1
Dergi makalesi
Açık
Doxorubicin-induced testicular damage is related to PARP-1 signaling molecules in mice
Oluşturanlar
- 1. Biruni Univ, Fac Med, Dept Histol & Embryol, Istanbul, Turkey
- 2. Akdeniz Univ, Fac Med, Dept Histol & Embryol, Antalya, Turkey
- 3. Akdeniz Univ, Fac Med, Dept Pharmacol, Antalya, Turkey
- 4. Yeni Yuzyil Univ, Fac Med, Dept Obstet & Gynecol, Istanbul, Turkey
Açıklama
Background: Doxorubicin (DOX), is a chemotherapeutic agent, which evokes oxidative stress and cell apoptosis in testicular tissue. It is known that the activation of the nuclear enzyme poly (ADP-ribose) polymerase (PARP), leading to apoptosis induced by DOX. The aim of the present study is to investigate whether PARP pathway has a role in DOX-induced testicular damage and infertility utilizing pharmacological PARP-1 inhibitor, PJ34, and PARP-1 knockout mice model.
Dosyalar
bib-3e0d26a6-ffb1-421e-8ed2-165d6da26858.txt
Dosyalar
(227 Bytes)
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227 Bytes | Ön İzleme İndir |