Published January 1, 2019
| Version v1
Journal article
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Awake Mouse Imaging: From Two-Photon Microscopy to Blood Oxygen Level-Dependent Functional Magnetic Resonance Imaging
Creators
- Desjardins, Michele
- Kilic, Kivilcim
- Thunemann, Martin1
- Mateo, Celine2
- Holland, Dominic1
- Ferri, Christopher G. L.1
- Cremonesi, Jonathan A.3
- Li, Baoqiang4
- Cheng, Qun1
- Weldy, Kimberly L.1
- Saisan, Payam A.1
- Kleinfeld, David
- Komiyama, Takaki
- Liu, Thomas T.5
- Bussell, Robert5
- Wong, Eric C.5
- Scadeng, Miriam5
- Dunn, Andrew K.6
- Boas, David A.7
- Sakadzic, Sava4
- Sakadzic, Sava4
- 1. Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
- 2. Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA
- 3. Univ Calif San Diego, Biol Undergrad Program, La Jolla, CA 92093 USA
- 4. Harvard Med Sch, Martinos Ctr Biomed Imaging, Massachusetts Gen Hosp, Charlestown, MA 02115 USA
- 5. Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA
- 6. Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA
- 7. Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA
Description
BACKGROUND: Functional magnetic resonance imaging (fMRI) in awake behaving mice is well positioned to bridge the detailed cellular-level view of brain activity, which has become available owing to recent advances in microscopic optical imaging and genetics, to the macroscopic scale of human noninvasive observables. However, though microscopic (e.g., two-photon imaging) studies in behaving mice have become a reality in many laboratories, awake mouse fMRI remains a challenge. Owing to variability in behavior among animals, performing all types of measurements within the same subject is highly desirable and can lead to higher scientific rigor.
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