Modeling and Analysis of the Cross-talk Regulators Between the AKT and ERK Signaling Pathways

The cross-talk between different signal transduction pathways plays a key role in the regulation of cellular functions. This paper models the major feedback loops involved in the cross-talk between AKT and ERK signaling pathways. The developed models can be used to improve our understanding of the complex interactions between two important pathways at the systems level. (C) 2019, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.