Published January 1, 2019
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Serum choline and butyrylcholinesterase changes in response to endotoxin in calves receiving intravenous choline administration
Creators
- 1. Eskisehir Osmangazi Univ, Med & Surg Lab Anim Res & Practice Ctr, TR-26480 Eskisehir, Turkey
- 2. Univ Murcia, Interlab UMU, Interdisciplinary Lab Clin Pathol, E-30100 Murcia, Spain
- 3. Uludag Univ, Fac Vet Med, Dept Internal Med, TR-16059 Bursa, Turkey
- 4. Uludag Univ, Fac Med, Dept Pharmacol, TR-16059 Bursa, Turkey
- 5. Acibadem Mehmet Ali Aydinlar Univ, Fac Med, Dept Pharmacol, Istanbul, Turkey
Description
Endotoxemia treatment options are still of interest due to high mortality and choline treatment is one of them because of its role in the cholinergic anti-inflammatory pathway. This study investigated serum choline and butyrylcholinesterase (BChE) responses, and their correlations with inflammatory, oxidative stress and tissue damage biomarkers, including paraoxanase-1 (PON1), and clinical signs in calves with endotoxemia and the effect of choline treatment in these responses. Healthy calves (n = 20) were divided equally into 4 groups: Control (0.9% NaCl, iv), Choline (C; 1 mg/kg/iv,once), Lipopolysaccharide (LPS; 2 mu g/kg/iv,once) and LPS + C. Clinical and laboratory examinations were performed before and 0.5-48 h (hrs) after treatments.
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