Published January 1, 2019
| Version v1
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Rho-kinase is a negative regulator of red blood cell eNOS under basal conditions
- 1. Akdeniz Univ, Dept Physiol, Med Fac, TR-07070 Antalya, Turkey
- 2. Akdeniz Univ, Dept Med Microbiol, Med Fac, Antalya, Turkey
- 3. Akdeniz Univ, Med Fac, Dept Biophys, Antalya, Turkey
Description
BACKGROUND: Rho-kinase, an effector of the small GTPase RhoA, is known to be a novel inhibitory regulator of eNOS in endothelial cells under basal conditions and disease states. However, although RBC possesses active RhoA/Rho-kinase pathway, Rho-kinase mediated eNOS regulation has not been investigated in RBC, so far.
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