Published January 1, 2019
| Version v1
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A bioactive product lipoxin A4 attenuates liver fibrosis in an experimental model by regulating immune response and modulating the expression of regeneration genes
Creators
- 1. Inonu Univ, Sch Med, Dept Med Biol & Genet, Malatya, Turkey
- 2. Inonu Univ, Sch Med, Dept Histol & Embryol, Malatya, Turkey
- 3. Karabuk Univ, Sch Med, Div Gastroenterol, Dept Internal Med, Karabuk, Turkey
- 4. Abant Izzet Baysal Sch Med, Div Gastroenterol, Dept Internal Med, Bolu, Turkey
- 5. Inonu Univ, Sch Med, Dept Surg, Liver Transplantat Inst, Malatya, Turkey
Description
Background/Aims: Lipoxin A4 (LXA4), an anti-inflammatory lipid mediator, regulates leukocyte cellular activity and activates gene transcription. The therapeutic effect of LXA4 on liver fibrosis and its mechanism on the immune system are largely unknown. Because the regenerative capacity of hepatocytes in acute and chronic liver failure models of mouse increases by silencing MKK4, we aimed to investigate the effect of parenteral administration of LXA4 on the genes responsible for regeneration of liver, namely MKK4, MKK7, and ATF2, and visualize the therapeutic effects in an experimental model.
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