Published January 1, 2019
| Version v1
Journal article
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Antidepressant-like Effects Induced by Chronic Blockade of the Purinergic 2X7 Receptor through Inhibition of Non-like Receptor Protein 1 Inflammasome in Chronic Unpredictable Mild Stress Model of Depression in Rats
Creators
- 1. Istanbul Univ, Aziz Sancar Inst Expt Med Res, Dept Neurosci, TR-34390 Istanbul, Turkey
- 2. Marmara Univ, Sch Med, Dept Histol & Embryol, Istanbul, Turkey
- 3. Kocaeli Univ, Sch Med, Dept Pharmacol, Kocaeli, Turkey
Description
Objective: Purinergic 2X7 receptor (P2X7R) activation is known to be involved in pathogenesis of depression. Our aims were to investigate P2X7R-activated inflammasome pathways in parallel with induction of depression and to test the antidepressant-like effects of the selective P2X7R antagonist Brilliant Blue G (BBG) in a rat model of chronic unpredictable mild stress (CUMS).
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