Yayınlanmış 1 Ocak 2019 | Sürüm v1
Dergi makalesi Açık

Cyclosporine-A induces apoptosis in human prostate cancer cells PC3 and DU145 via downregulation of COX-2 and upregulation of TGF beta

  • 1. Cumhuriyet Univ, Fac Pharm, Dept Biochem, Sivas, Turkey
  • 2. Cumhuriyet Univ, Sch Med, Dept Pharmacol, Sivas, Turkey

Açıklama

Background: Potential targets for prostate cancer therapy are urgently needed for curative of patients. Cyclosporine-A (CsA), an immunosuppressive and a selective cyclooxygenase-2 (COX-2) inhibitor, exerts antitumor activity. However, the molecular effects of CsA is not fully understood in prostate cancer. In this research, we sought to determine role and mechanism of CsA in prostate cancer.

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