Published January 1, 2019 | Version v1
Journal article Open

The role of atopy in the pathogenesis of bleomycin pulmonary toxicity

  • 1. Koc Univ, Sch Med, Dept Allergy & Immunol, Istanbul, Turkey
  • 2. Istanbul Univ, Aziz Sancar Inst Expt Med, Dept Immunol, Istanbul, Turkey
  • 3. Koc Univ Hosp, Dept Allergy & Immunol, Istanbul, Turkey
  • 4. Koc Univ Hosp, Dept Haematol, Istanbul, Turkey
  • 5. Koc Univ, Sch Med, Dept Infect Dis, Istanbul, Turkey
  • 6. Koc Univ, Sch Med, Dept Resp Med, Istanbul, Turkey
  • 7. Koc Univ, Sch Med, Dept Haematol, Istanbul, Turkey

Description

Introduction: Bleomycin pulmonary toxicity (BPT) is a potentially life-threatening consequence of bleomycin usage in patients. An overproduction of epithelium-derived cytokines, habitually linked to allergic inflammation, has been recently revealed in experimental models of BPT.

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