Published January 1, 2019
| Version v1
Journal article
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Phthalocyanine-based mesoporous organosilica nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization
Creators
- 1. Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Turkey
- 2. Univ Montpellier, Inst Biomol Max Mousseron, UMR 5247, 15 Ave Charles Flahault, F-34093 Montpellier 05, France
- 3. CNRS, Inst Charles Gerhardt Montpellier, UMR 5253, UM,ENSCM, Cc 1701,Pl Eugene Bataillon, F-34095 Montpellier 05, France
Description
Mesoporous organosilica nanoparticles (PHT-PMO) have been prepared from an octa-triethoxysilylated Zn phthalocyanine precursor. These PHT-PMO nanoparticles had no dark toxicity but high phototoxicity when irradiated at 650 nm, and remarkable near-infrared phototoxicity when excited at 760 and 810 nm. The PHT-PMO were then aminated to promote electrostatic complexation with siRNA. Transfection experiments were performed upon NIR irradiation and photochemical internalization was very efficient, leading to 65% luciferase extinction in MCF-7 cancer cells expressing stable luciferase.
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