Published January 1, 2014
| Version v1
Journal article
Open
Design of a Gd-DOTA-Phthalocyanine Conjugate Combining MRI Contrast Imaging and Photosensitization Properties as a Potential Molecular Theranostic
Creators
- 1. Gebze Inst Technol, Dept Chem, TR-41400 Gebze, Turkey
- 2. Bilkent Univ, Inst Mat Sci & Nanotechnol, Natl Nanotechnol Res Ctr UNAM, Ankara, Turkey
- 3. Bilkent Univ, Natl Magnet Resonance Res Ctr UMRAM, Ankara, Turkey
- 4. Inst Chem Biol & Fundamental Med, Novosibirsk, Russia
- 5. Yildiz Tech Univ, Arts & Sci Fac, Dept Phys, Istanbul, Turkey
Description
The design and synthesis of a phthalocyanine - Gd-DOTA conjugate is presented to open the way to novel molecular theranostics, combining the properties of MRI contrast imaging with photodynamic therapy. The rational design of the conjugate integrates isomeric purity of the phthalocyanine core substitution, suitable biocompatibility with the use of polyoxo water-solubilizing substituents, and a convergent synthetic strategy ended by the use of click chemistry to graft the Gd-DOTA moiety to the phthalocyanine. Photophysical and photochemical properties, contrast imaging experiments and preliminary in vitro investigations proved that such a combination is relevant and lead to a new type of potential theranostic agent.
Files
bib-69fbb6b2-ea54-4a89-a6a4-361e378e2b2a.txt
Files
(372 Bytes)
| Name | Size | Download all |
|---|---|---|
|
md5:90f54dad7dce5be665b0d800e887061a
|
372 Bytes | Preview Download |