Yayınlanmış 1 Ocak 2014
| Sürüm v1
Dergi makalesi
Açık
Promoter Methylation in Epithelial-Enriched and Epithelial-Depleted Cell Populations Isolated from Breast Milk
Oluşturanlar
- 1. Univ Massachusetts, Dept Vet & Anim Sci, Amherst, MA 01003 USA
- 2. Yeditepe Univ, Dept Physiol, Fac Med, TR-34755 Istanbul, Turkey
- 3. Yeditepe Univ, Dept Pediat, Fac Med, TR-34755 Istanbul, Turkey
- 4. Univ S Carolina, Dept Sociol, Columbia, SC 29208 USA
Açıklama
Background: Breast cancer is the most frequently diagnosed cancer among Turkish women and both the incidence and associated mortality appear to be increasing. Of particular concern is the percentage of young women diagnosed with breast cancer; roughly 20% of all breast cancer diagnoses in Turkey are in women younger than 40 years. Increased DNA methylation in the promoter region of tumor suppressor genes is a promising molecular biomarker, and human milk provides exfoliated breast epithelial cells appropriate for DNA methylation analyses. Comparisons between DNA methylation patterns in epithelial (epithelial-enriched) and nonepithelial (epithelial-depleted) cell fractions from breast milk have not been reported previously.
Dosyalar
bib-604670e2-8a8a-4bff-b41b-2f6b41c4b6b3.txt
Dosyalar
(270 Bytes)
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md5:b0b10ee4607fa782351d41fb9d8b4c73
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270 Bytes | Ön İzleme İndir |