Yayınlanmış 1 Ocak 2014
| Sürüm v1
Dergi makalesi
Açık
Synthesis of diarylmethylamines via palladium-catalyzed regioselective arylation of 1,1,3-triaryl-2-azaallyl anions
Oluşturanlar
- 1. Univ Penn, Dept Chem, Philadelphia, PA 19104 USA
Açıklama
Diarylmethylamines are of great interest due to their prevalence in pharmaceutical chemistry. As a result, new methods for their synthesis are in demand. Herein, we report a versatile protocol for the synthesis of diarylmethylamine derivatives involving palladium-catalyzed arylation of in situ generated 2-azaallyl anion intermediates. The 2-azaallyl anions are generated by reversible deprotonation of readily available aldimine and ketimine precursors. Importantly, the arylated aldimine and ketimine products do not undergo isomerization under the reaction conditions. Scale-up of the arylation and hydrolysis of the resulting products to furnish diarylmethylamines were also successfully performed.
Dosyalar
bib-154881bf-aab1-46b6-93e8-d15422f9b70c.txt
Dosyalar
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