Published January 1, 2014
| Version v1
Journal article
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Nucleophilic substitution reactions of 1,4-naphthoquinone and biologic properties of novel S-, S,S-, N-, and N,S-substituted 1,4-naphthoquinone derivatives
Creators
- 1. Istanbul Univ, Fac Engn, Dept Chem, Istanbul, Turkey
- 2. Beykent Univ, Fac Engn & Architecture, Dept Chem Engn, Istanbul, Turkey
- 3. Natl Univ Lviv Polytech, Dept Technol Biol Act Subst Pharm & Biotechnol, Lvov, Ukraine
Description
A novel series of S-, S,S-, N- and N,S-substituted 1,4-naphthoquinone derivatives were synthesized and evaluated for their antibacterial and antifungal activity. Among the synthesized compounds especially 10a and 11b have been discovered as an antibacterial or antifungal agents, and 15f is the most effective compound against M. luteum as potent antifungal. The structures of the novel products were characterized by micro analysis, UV/Vis, H-1 NMR, C-13 NMR, and MS. The electrochemical properties of some of the novel 1,4-naphthoquinone derivatives were also investigated by cyclic voltammetry.
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