Published January 1, 2014 | Version v1
Journal article Open

Synthesis of tertiary propargylic phosphonates by addition of trialkynylaluminum reagents to acyl phosphonates and investigation of their antimicrobial activities

  • 1. Middle E Tech Univ, Dept Chem, TR-06531 Ankara, Turkey
  • 2. Canakkale Onsekiz Mart Univ, Fac Engn & Architecture, Dept Chem Engn, Canakkale, Turkey
  • 3. Eskisehir Osmangazi Univ, Grad Sch Nat & Appl Sci, Eskisehir, Turkey
  • 4. Eskisehir Osmangazi Univ, Fac Sci & Arts, Dept Biol, Eskisehir, Turkey

Description

A series of propargylic alcohols containing phosphonates was synthesized by addition reactions of tris-(propynyl) and tris-(phenylethynyl) aluminum reagents to acyl phosphonates in good yields. Aromatic moieties of the acyl phosphonates with electron-withdrawing groups generally resulted in better isolated chemical yield. Selected propargylic phosphonates were tested for antimicrobial activities. Compounds 3a and 3h showed noticeable antifungal activity, especially against molds.

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