Yayınlanmış 1 Ocak 2014
| Sürüm v1
Dergi makalesi
Açık
A heterodimeric [RGD-Glu-[Cu-64-NO2A]-6-Ahx-RM2] alpha(v)beta(3)/GRPr-targeting antagonist radiotracer for PET imaging of prostate tumors
Oluşturanlar
- 1. Harry S Truman Mem Vet Hosp, Div Res, Columbia, MO 65201 USA
- 2. Univ New Mexico, Coll Pharm, Albuquerque, NM 87131 USA
Açıklama
Introduction: In the present study, we describe a Cu-64-radiolabeled heterodimeric peptide conjugate for dual alpha(v)beta(3)/GRPr (alpha(v)beta(3) integrin/gastrin releasing peptide receptor) targeting of the form [RGD-Glu-[Cu-64-NO2A]-6-Ahx-RM2] (RGD: the amino acid sequence [Arg-Gly-Asp], a nonregulatory peptide used for alpha(v)beta(3) integrin receptor targeting; Glu: glutamic acid; NO2A: 1,4,7-triazacyclononane-1,4-diacetic acid; 6-Ahx: 6-amino hexanoic acid; and RM2: (D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2), an antagonist analogue of bombesin (BBN) peptide used for GRPr targeting).
Dosyalar
bib-0ce77d7f-2ac8-4d44-a913-aa99cebb553e.txt
Dosyalar
(326 Bytes)
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326 Bytes | Ön İzleme İndir |