Yayınlanmış 1 Ocak 2014
| Sürüm v1
Dergi makalesi
Açık
The effect of amygdala kindling on neuronal firing patterns in the lateral thalamus in the GAERS model of absence epilepsy
Oluşturanlar
- 1. Istanbul Univ, Fac Pharm, Dept Pharmacol, Istanbul, Turkey
- 2. Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Vic 3050, Australia
- 3. Marmara Univ, Dept Pharmacol & Clin Pharmacol, Sch Med, TR-34668 Istanbul, Turkey
Açıklama
ObjectiveThe co-occurrence of absence and mesial temporal lobe epilepsy is rare in both humans and animal models. Consistent with this, rat models of absence epilepsy, including genetic absence epilepsy rats from Strasbourg (GAERS), are resistant to experimental temporal lobe epileptogenesis, in particular by amygdala kindling. Structures within the cortical-thalamocortical system are critically involved in the generation and maintenance of the electrographic spike-and-wave discharges (SWDs) that characterize absence seizures. Using in vivo electrophysiologic recordings, this study investigated the role of thalamocortical circuitry in the generalization of amygdala-kindling induced seizures in the GAERS and the nonepileptic control (NEC) strain of Wistar rats.
Dosyalar
bib-95e8b57a-d109-4571-8180-114a2be63529.txt
Dosyalar
(286 Bytes)
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286 Bytes | Ön İzleme İndir |