Biodegradable non-aromatic adhesive polyurethanes based on disaccharides for medical applications

This work addresses synthesis, characterization, adhesive properties, protein adsorption and in vitro biodegradation of non-aromatic polyurethanes (NPUs). The following reactants were used in the syntheses of polyurethanes (PUs): non-aromatic 4,4'-Methylenebis(cyclohexyl isocyanate) (MCI), disaccharides (maltose and sucrose) and polyethylene glycol 200 (PEG 200). The NPUs exhibited low glass transition temperature (T-g) and good thermal stability. The dynamic contact angles on NPUs were influenced by the ratios of PEG 200-disaccharide monomer and the hard segment of the NPUs. The highest adhesion strength in whole polyurethanes was found as 307.6 +/- 50.1 kPa for 15% sucrose containing polyurethane. Protein adsorptions of polyurethane films were measured as average 10 pg Bovine Serum Albumin (BSA)/cm(2) and 5 mu g fibrinogen/cm(2) for maltose, and 15 mu g BSA/cm(2) and 5 mu g fibrinogen/cm(2) for sucrose. Biodegradability ratios of NPUs were in the range of 15-35% for 8 weeks depending on the disaccharides containing NPUs. (C) 2013 Elsevier Ltd. All rights reserved.