Published January 1, 2014
| Version v1
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Synthesis of Spirocyclic and Tricyclic Isoxazoline via 1,3-Dipolar Cycloaddition Reactions
Creators
- 1. Amasya Univ, Dept Chem, Fac Sci & Arts, TR-05100 Merkez Amasya, Turkey
- 2. Sakarya Univ, Dept Chem, Fac Sci & Arts, TR-54187 Serdivan Sakarya, Turkey
Description
1,3-Dipolar cycloadditions of the bicyclic monoterpenes (S)-(-)-camphene (1), (R)-(+)-a-pinene (2), and (S)-(-)-b-pinene (3) with aryl and heteroaryl nitrile oxides afforded new spirocyclic and tricyclic isoxazoline derivatives 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 whose biological activities were evaluated in bioassay studies.
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